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Don't leave live food in with your reptile unsupervised. Mice and rats bite back, and sometimes they even win. King mealworms and crickets can also do some damage to your pet, though they can usually be safely left in a cage that has a bit of apple or bran in it so they'll chew that instead of your reptile.
Live animals also carry diseases and parasites, which can be killed by freezing and thawing the animal before feeding.